In flexible (Type F) tissues all cells are assumed to have the potential for proliferation and are also engaged in tissue-specific functions. The pronounced dose-latency relationship results from the dose-dependent loss of proliferating functional cells through their mitotic death, together with the feedback-mediated stimulation of compensatory proliferation, leading to an even enhanced cell loss by doomed divisions.
ICRP Glossary entry - June 2019
Return to Glossary