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<blockquote> The manifestations of tissue injury vary from one tissue to another depending on cellular composition, proliferation rate, and mechanisms of response to radiation, which may be highly tissue specific. Examples ... include cataracts of the lens of the eye, non-malignant damage to the skin, cell depletion in the bone marrow causing haematological deficiencies, and gonadal cell damage leading to impairment of fertility. Tissue reactions, especially late reactions, also depend on damage to blood vessels or elements of the extracellular matrix, which are common to most organs of the body. </blockquote>